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Examples of SNRIs include duloxetine (Cymbalta and Yentreve) and venlafaxine (Efexor).
NASSAs may be effective for some people who are unable to take SSRIs.
Examples of TCAs include amitriptyline (Tryptizol), clomipramine (Anafranil), imipramine (Tofranil), lofepramine (Gamanil) and nortriptyline (Allegron).
Some types of TCAs, such as amitriptyline, can also be used to treat chronic nerve pain.
The Royal College of Psychiatrists estimates that 50 to 65% of people treated with an antidepressant for depression will see an improvement, compared to 25 to 30% of those taking a placebo. When they're prescribed, you'll start on the lowest possible dose thought necessary to improve your symptoms.
Antidepressants usually need to be taken for 1 or 2 weeks (without missing a dose) before the benefit starts to be felt.
The most common side effects of antidepressants are usually mild.
They also cause more unpleasant side effects than SSRIs and SNRIs.The side effects of NASSAs are similar to those of SSRIs, but they're thought to cause fewer sexual problems.However, they may also cause more drowsiness at first.However, the evidence that SNRIs are more effective in treating depression is uncertain.It seems that some people respond better to SSRIs, while others respond better to SNRIs.